Welcome to your Downtown opportunity. Whether you’re a business owner looking for an accessible storefront, an investor eyeing mixed-use potential, or a developer ready to make your mark, downtown Rochester sits at the center of one of the most dynamic economic engines in the Midwest. Anchored by Mayo Clinic—the state’s largest employer—and fueled by unprecedented public and private investment through the Destination Medical Center (DMC) initiative, downtown is evolving rapidly. This walkable, historic, and increasingly dense core is where global healthcare innovation, new housing, hospitality, and commerce converge, positioning Rochester for sustained growth and long-term vitality over the next decade.
How to Get Started
- Explore available listings - both for lease and for sale - through local commercial real estate brokers.
- Talk with a broker or advisor to assess financing, zoning, and potential build-out costs.
- Review downtown-specific resources, like historic district regulations, public-realm plans, and RDA grant programs.
- Connect with the RDA to learn about connection points, community programs, and business activation opportunities (like retail popups).
- Bring your vision to life. Whether you’re launching a boutique shop, new office space, or mixed-use development, downtown Rochester is ready for your next chapter.
Commercial Real Estate Brokers & Firms
- Core Real Estate Group
- Hamilton Real Estate Group
- LOAM Commercial Real Estate
- North Rock Real Estate
- Realty Growth, Inc.
Click here to connect with the Do Business Downtown team
COMING SOON: A map of all available listings in downtown Rochester
